QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Summary Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Berditchevski, F. Search for Related Content PubMed PubMed Citation Articles by Berditchevski, F. Social Bookmarking                         What's this?

Complexes of tetraspanins with integrins: more than meets the eye

CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK

View larger version (20K): [in a new window]   Fig. 1. Schematic representation of a generic tetraspanin. The CCG motif and the position of the last cysteine residue in the large extracellular loop are conserved in all tetraspanins. The PxxCC motif is found in >65% of tetraspanins. Encircled residues are found in > 60% of tetraspanins. Most tetraspanins (with the exception of CD81 and NET-2) have a consensus site for N-linked glycosylation in the large extracellular loop (LECL) (marked as ). Note that a glycosylation site for CD9 was mapped to the small extracellular loop. * The N-terminal region of oculospanin contains 78 residues. ** The C-terminal regions of RDS-1, ROM-1 and NET-2 contain 63, 65 and 63 residues, respectively.

View larger version (35K): [in a new window]   Fig. 2. A hypothetical model showing how integrin-tetraspanin complexes may influence cell migration.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

Twitter