spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Summary Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dorée, M.
Right arrow Articles by Hunt, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dorée, M.
Right arrow Articles by Hunt, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?

Marcel Dorée1 and Tim Hunt2

1 CRBM, UPR 1086-CNRS, 1919 route de Mende, 34293 Montpellier Cedex 5, France
2 ICRF, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK



View larger version (23K):

[in a new window]
  		Fig. 1. Two early models to explain how cyclin activates MPF (Minshull et al., 1989bGo), published a few months before MPF was identified as a stoichiometric complex comprising one molecule of Cdc2 and one molecule of cyclin B. The upper cartoon shows cyclin as binding and thereby removing a hypothetical anti-MPF subunit, thus activating Cdc2. According to this diagram, anti-MPF acts stoichiometrically, but both anti-MPF and cyclin might act catalytically, for example to alter the phosphorylation state of Cdc2. In the lower model, cyclin modifies the hypothetical inhibitor, which allows Cdc2 dephosphorylation.

 

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



© The Company of Biologists Ltd 2002