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Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases

Alison Hindley1 and Walter Kolch1,2,*

1 The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, G61 1BD, UK
2 Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK



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  		Fig. 1. Putative Raf signalling targets. All functional interactions shown have been described for Raf-1 only, with the exception of MEK phosphorylation which is common to all three Raf proteins. Red arrows with black frames indicate validated substrate phosphorylations, while red arrows indicate suggested substrates. Black arrows are used to describe functional interactions of uncharacterised nature, which may or may not include phosphorylation. See text for details.

 


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  		Fig. 2. Subcellular compartmentalization and protein interactions may determine the specificity of Raf activation and signalling. See text for details.

 

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