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First published online July 31, 2003
doi: 10.1242/10.1242/jcs.00669

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Myosin VI: two distinct roles in endocytosis

Division of Biological Sciences, Section of Cell and Developmental Biology, University of California at San Diego, 2129 Bonner Hall, MC 0368, 9500 Gilman Drive, La Jolla, CA 92093-0368, USA (e-mail: tama{at}ucsd.edu)

View larger version (100K): [in a new window]   Fig. 1. Myosin VI is located at the base of microvilli. Confocal image of a frozen section of mouse kidney stained with antibodies to myosin VI (visualized with a FITC-conjugated secondary antibody) and rhodamine-conjugated phalloidin to stain F-actin. Actin (red) is most prominent in apical microvilli in the proximal tubules of the kidney. Myosin VI (green) is enriched in the endocytic region at the base of the microvilli. Bars, 10 µm.

View larger version (25K): [in a new window]   Fig. 2. Three models for myosin VI function in endocytosis. Depicted are two microvilli filled with polarized actin filaments (arrows) and the endocytic region found between them. See text for details.

View larger version (11K): [in a new window]   Fig. 3. Myosin VI splice forms.

View larger version (20K): [in a new window]   Fig. 4. The three linker proteins that associate with the globular tail domain of myosin VI: Dab2, GIPC and Sap97. Dab2 is alternatively spliced and so only the major splice forms are shown. See text for an explanation of domains found in each protein. The myosin VI-binding domains for all three linker proteins are shown in light blue.