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First published online November 18, 2003
doi: 10.1242/10.1242/jcs.00908

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Wee1-dependent mechanisms required for coordination of cell growth and cell division

Sinsheimer Laboratories, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, CA 95064, USA

View larger version (13K): [in a new window]   Fig. 1. Comparison of the effects of wee1- and cdc25- mutants in fission yeast and swe1 and mih1 in budding yeast. cdc25- mutants arrest at G2/M in fission yeast, whereas mih1 cells undergo a delay but eventually enter mitosis. In wild-type budding yeast, the daughter cell is smaller than the mother cell, but undergoes additional growth during G1 (Hartwell and Unger, 1977).

View larger version (11K): [in a new window]   Fig. 2. A G1 cell-size checkpoint ensures that budding yeast daughter cells that are below a critical size spend more time in G1 undergoing growth before entering the cell cycle. As a result, a population of swe1 cells will consist of newly born daughter cells that are abnormally small, and mother cells that are of a normal size.

View larger version (11K): [in a new window]   Fig. 3. A model for entry into mitosis based on work in fission yeast and Xenopus. Work in Xenopus suggests that Polo kinase might be required for activation of Cdc5 and entry into mitosis; however, work in fission yeast suggests that Polo kinase might not be required for entry into mitosis (see text). Kinases are shown in yellow and phosphatases are shown in pink.

View larger version (18K): [in a new window]   Fig. 4. Dependency relationships in the signaling network required for Swe1 regulation in budding yeast. Kinases are shown in yellow and phosphatases are shown in pink.

View larger version (19K): [in a new window]   Fig. 5. Protein-protein interactions that have been detected thus far in the signaling network required for Swe1 regulation in budding yeast. The interaction between Swe1 and Clb2/Cdc28 is unpublished data (S. Harvey, A. Sreenivasan and D.K.). Kinases are shown in yellow.

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