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doi: 10.1242/10.1242/jcs.00249

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Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals

Enzo Lalli1,*, Kenji Ohe1, Elisa Latorre2, Marco E. Bianchi2 and Paolo Sassone-Corsi1,*

1 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, B.P. 163, 67404 Illkirch, Strasbourg, France
2 Università San Raffaele, Via Olgettina 58, 20132 Milano, Italy



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  		Fig. 1. Mechanisms for SRY and SOX protein function in pre-mRNA splicing. (a) Possible interaction with structures mimicking a four-way junction that favors spliceosome rearrangements during splicing (redrawn from Steitz, 1992Go). (b) Activation (top) or repression (bottom) of alternative splice site usage through binding to specific RNA sequences.

 


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  		Fig. 2. Regulatory cascades in D. melanogaster and mammalian sex determination involve factors acting upon pre-mRNA splicing. In the fly (left) SXL positively regulates TRA expression and downregulates MSL-2 in female flies. TRA-TRA2 heterodimers trigger expression of the female-specific DSXF isoform. In the absence of SXL, males express DSXM. In mammals (right), WT1(+KTS) isoforms upregulate Sry in the developing male gonad. Sry, in turn, negatively influences the expression — or the function — of an unknown Z gene, which inhibits testis differentiation genes. Z gene candidates are indicated (pink box).

 




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