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First published online 29 January 2003
doi: 10.1242/jcs.00283

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Abnormal tissue-dependent polytenization of a block of chromosome 3 pericentric heterochromatin in Drosophila melanogaster

¹ Department of Cytology and Genetics, Novosibirsk State University, Novosibirsk 630090, Russia
² Department of Cytology and Genetics, Novosibirsk 630090, Russia

View larger version (10K): [in a new window]   Fig. 1. Location of the deficiency break points (A) and DNA clones (C) in chromosome 3 mitotic heterochromatin (B) (Koryakov et al., 2002). Numbers 47-58 (B) denote differentially stained heterochromatic regions. Gray and black lines indicate the largest and the smallest limits of the deficiencies, respectively.

View larger version (62K): [in a new window]   Fig. 2. Morphology of the chromosome 3 heterochromatin in polytene chromosomes from SGs of Oregon-R (A) and SuUR mutants (B), from NCs of otu mutants (C,E) and otu; SuUR mutants (D,F,G). Homologous regions are connected by lines. Bar, 5 µm.

View larger version (173K): [in a new window]   Fig. 3. Heterozygous heterochromatic deficiencies in SG chromosomes of SuUR (A,C,E) and NCs of otu mutants (B,D,F,G): Df(3L)1-16 (A,B), Df(3L)2-66 (C,D), Df(3L)6B-29 + Df(3R)6B-29 (E,F,G). The material removed by the deficiency is marked by a bracket in the normal homolog (D). See text for explanation of the arrows. Bar, 5 µm.

View larger version (77K): [in a new window]   Fig. 4. FISH of the satellite clones AAGAG (A,E), AATAACATAG (B,F), dodecasatellite (C,G), 1.688 (D) and AACAC (H) on the SG (A,B,C,D) and NC (E,F,G,H) polytene chromosomes. Arrows indicate localization of the label. Bar, 5 µm.

View larger version (74K): [in a new window]   Fig. 5. Correspondence between heterochromatin in SG chromosomes of SuUR mutants (A,D), mitotic chromosomes (B,E) and NC chromosomes of otu-SuUR nutants (C,F). Location of satellite sequences (A-C) and rearrangements and genes (D-F). Panel G demonstrates regions of mitotic heterochromatin polytenizing both in SG and NC chromosomes. Bar, 3 µm.