QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online May 28, 2005
doi: 10.1242/10.1242/jcs.02398

This Article Summary Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tanoue, T. Articles by Takeichi, M. Search for Related Content PubMed PubMed Citation Articles by Tanoue, T. Articles by Takeichi, M. Social Bookmarking                         What's this?

New insights into Fat cadherins

RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan

View larger version (14K): [in a new window]   Fig. 1. Schematic representation of the cadherin superfamily. Fat cadherin is the largest cadherin, with 34 cadherin repeats. Blue ovals and green circles indicate cadherin repeats and laminin A-G motifs, respectively. Yellow boxes indicate EGF motifs. The red box in Flamingo indicates the flamingo box. Classical cadherin is believed to associate with the actin cytoskeleton through the ß-catenin and -catenin complex (pink oval). Desmosomal cadherins associate with intermediate filaments through plakoglobin/desmoplakin (light blue oval). The variously colored rectangles indicate the intracellular domains of the cadherins.

View larger version (24K): [in a new window]   Fig. 2. Members of the Fat and Dachsous cadherin subfamilies. Drosophila has two Fat cadherins (Fat and Fat-like) and one Dachsous cadherin. In vertebrates, four Fat cadherins (Fat-J, Fat1, Fat2 and Fat3) and two Dachsous cadherins (Dachsous 1 and Dachsous 2) have been reported. Fat-J is probably the counterpart of Drosophila Fat. Fat1 and Fat3 resemble each other in their overall sequences, and they show weak similarity to Drosophila Fat-like. The precise length of Dachsous 2 has not been determined. The rectangular boxes depict the intracellular domains of the various Fats. The regions between the last cadherin repeat and the first EGF motif or the laminin A-G motif (for Fat2) of Fat cadherins show weak similarities to the Flamingo box, which is conserved in Flamingo cadherins (Usui et al., 1999).

View larger version (7K): [in a new window]   Fig. 3. A phylogenic tree of Fat cadherins. Full-length sequences of these molecules are compared.

View larger version (11K): [in a new window]   Fig. 4. Potential signaling cascades in Fat-dependent regulation of planar cell polarity (PCP). Four-jointed and Dachsous regulate (probably negatively) Fat. How Four-jointed and Dachsous regulate Fat and how Fat regulates the PCP pathway have not been currently clarified.

View larger version (20K): [in a new window]   Fig. 5. Fat1 appears to be involved in cell-cell contacts and lamellipodial dynamics at the leading edge. Fat1 localizes to early cell-cell contact sites, lamellipodial edges and the basolateral portion of polarized epithelia (red). Fat1 regulates actin dynamics by binding to Ena/VASP proteins at these sites. Whether Fat1 cadherins undergo homophilic interactions remains unknown.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

Twitter