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First published online October 12, 2006
doi: 10.1242/10.1242/jcs.03227

Journal of Cell Science 119, 4155-4163 (2006)
Published by The Company of Biologists 2006
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Generation of noncentrosomal microtubule arrays

Francesca Bartolini and Gregg G. Gundersen*

Departments of Anatomy & Cell Biology and Pathology, Columbia University, New York, NY 10032, USA


Figure 1
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  		Fig. 1. Cells with noncentrosomal MT arrays.

 

Figure 2
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  		Fig. 2. The three-step hypothesis. Schematic diagram of the three steps in the formation of noncentrosomal MT arrays. (1) Upon receiving an initiating signal, MTs can be generated de novo at noncentrosomal sites or be released from the centrosome where they were nucleated. (2) Once formed, noncentrosomal MTs are translocated to sites of assembly, typically by MT-dependent motors. (3) Noncentrosomal MTs are stabilized and assembled into ordered arrays by MT capture and bundling. Depending on the cell type, noncentrosomal MTs can be arranged either (A) along the major axis of the cell as is the case in epithelia, myotubes, plant cells or S. pombe or (B) parallel to cellular processes as in neurons.

 

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© The Company of Biologists Ltd 2006