View larger version (16K):
[in this window]
[in a new window]
|
Fig. 1. Some of the possible mechanisms through which promoter selection of p53 can be regulated. On the left are mechanisms that contribute to the activation of a cell-cycle-arrest response. These include cooperation with other transcription factors, such as Miz, which may be necessary for activation of cell-cycle-arrest genes like p21WAF1/CIP1, as well as factors that repress the induction of apoptotic gene expression. On the right, are mechanisms that promote cell death through activation of apoptotic target genes. These may depend on increased levels of p53 protein, cooperating transcription factors such as NF- B, p53-binding proteins like ASPP, or post-translational modification of p53. Acetylation (Ac) has been linked to both increased and decreased expression of apoptotic target genes. These possibilities may be linked - for example, phosphorylation enhances interaction with proteins such as ASPP.
|
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
