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First published online December 20, 2006
doi: 10.1242/10.1242/jcs.03305

Journal of Cell Science 120, 7-15 (2007)
Published by The Company of Biologists 2007
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Centriole/basal body morphogenesis and migration during ciliogenesis in animal cells

Helen R. Dawe*,{ddagger}, Helen Farr* and Keith Gull

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK


Figure 1
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  		Fig. 1. Structures of centrioles and cilia. (A) The structure of the canonical motile 9+2 axoneme and its most common variation, the immotile 9+0 axoneme. (B) Schematic of a transverse section through the immature and mature centrioles. (C) Schematic of a longitudinal view of the mature centriole, showing the appendages, and a basal body with accessory structures.

 

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  		Fig. 2. Multiple pathways of ciliogenesis. Quiescent somatic cells use a single pre-existing mature centriole to subtend a transient primary cilium (Fig. 1 and Figure 2) lacking central pair microtubules, which is lost as the cell re-enters the cell cycle. In differentiated cells, several different types of single cilia can be produced from a mature centriole, such as the temporary (9+2 or 9+0) kinocilium (Figure 2), which may or may not possess the central pair microtubules (Flock and Duvall, 1965Go; Sobkowicz et al., 1995Go) and the primary (9+0) cilium produced on the luminal epithelium of kidney tubules (Figure 2). The pathways that produce several hundred cilia in epithelial cells in the mammalian airway are depicted at Figure 2 and Figure 2. Here, hundreds of centrioles are produced, duplicated either using the pre-existing centriole as a template (Figure 2), or formed via a non-templated method (Figure 2). The sperm flagellum produced in male meiosis is depicted at Figure 2. Green denotes 9+2 axonemes; dark blue denotes 9+0 axonemes; centrioles are shown in red; the deuterosome is shown in purple.

 

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  		Fig. 3. Ciliogenesis in rat trachea. (A) The first visible stage in the acentriolar pathway is the appearance of dense granules (arrowheads). (B) Procentrioles (P) form around deuterosomes (arrowheads). (C) Mature ciliated cells. The procentrioles have docked with the apical membrane to become basal bodies (arrowheads) and have extended cilia (Ci). Scale bars (A) and (B)=200 nm; (C)=5 µm.

 

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© The Company of Biologists Ltd 2007