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Fig. 2. Contribution of cohesin to cohesion in budding yeast depends on the locus involved. A summary of studies in which a loss of cohesion was observed at different loci in cohesin mutants is shown. These results indicate that the specific contribution of the cohesin complex to the cohesion of any two sister-chromatid loci is locus dependent. All the data refer to the loss of cohesion that has been measured in G2-M cells and the methods that were used to arrest the cells in mitosis are shown in brackets. Note that cdc16 and cdc20 cells arrest in mitosis in the presence of a functional spindle, whereas nocodazole (NOC) disrupts the spindle. The chromosome depicted in the figure is not drawn to scale and does not represent a particular yeast chromosome: the loci that are listed belong to different chromosomes. The colors reflect the level of penetrance of the loss-of-cohesion phenotype when cohesin mutations are present. Loci listed in red boxes show more loss of cohesion, meaning that cohesion at these loci depends mostly on the cohesin complex. Loci in the green boxes show an  50% loss of cohesion, suggesting that cohesin partially contributes to cohesion at these loci. Loci in the blue boxes show a very low loss of cohesion after cohesin mutation, meaning that chromosome cohesion at these loci depends mainly on mechanisms other than cohesin. Studies referenced in this schematic: 1(Antoniacci and Skibbens, 2006 ), 2(Lam et al., 2006), 3(Guacci et al., 1997), 4(Michaelis et al., 1997), 5(Mayer et al., 2001), 6(Suter et al., 2004), 7(Strom et al., 2007), 8(Toth et al., 1999), 9(Ciosk et al., 2000), 10(D'Amours et al., 2004), 11(Sullivan et al., 2004).
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