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Fig. 8. Localisation mechanism of pEg2. The N-terminal domain (red) localises the kinase to the centrosomes (grey) through an interaction with a hypothetical protein (blue) that binds to microtubules (black), the localisation being microtubule-dependent. Then the kinase binds to its substrates (yellow), which stabilises the localisation so that it becomes microtubule-independent.





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