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Fig. 1. Intracellular Cl- fluxes control Ca2+-elicited exocytosis. (A) Increases in cell capacitance ({Delta}C) evoked by infusion of the Ca2+- and ATP-containing control solution (ctrl, n=34) and in presence of niflumic acid (nifl, n=12) or DIDS (n=7). (B) Average rates of capacitance increase ({Delta}C/{Delta}t) ± s.e.m. (C) {Delta}C evoked as in (A) at 165 mM (n=10), 40 mM (n=8), and 2 mM (n=9) intracellular [Cl-] as indicated. (D) Average {Delta}C/{Delta}t ± s.e.m. Statistical significance was evaluated using Student’s t-test. *P<0.05; ***P<0.001.





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