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Fig. 4. Exocytosis requires granular acidic pH. (A) Capacitance increases ({Delta}C) elicited by infusion of the Ca2+- and ATP-containing control electrode solution (ctrl, n=21), after addition of sucrose (sucr, n=6) and in the presence of CCCP (n=6) or nigericin (nig, n=5). (B) Average rates of capacitance increase ({Delta}C/{Delta}t) ± s.e.m. (C) {Delta}C elicited by the control solution (ctrl, n=9), in the presence of the Na+/H+-exchanger inhibitor EIPA (n=10) and the v-H+-ATPase inhibitor bafilomycin (bafi, n=11). (D) Mean {Delta}C/{Delta}t ± s.e.m. ***P<0.001 **P<0.01.





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