Fig. 1. Organisation of p300/CBP proteins. (A) Comparison of p300 and CBP. The dark regions indicate the areas of highest homology, with the percentage amino acid identity between the two proteins indicated. The size of each protein, in number of amino acid residues, is indicated. (B) The functional domains in p300 are indicated, including the cysteine/histidine-rich domains CH1, CH2 and CH3, the KIX domain, the bromodomain (Br) and the ADA2 homology region. The N- and C-terminal domains of p300/CBP can act as transactivation domains, and the acetyl-transferase domain is located in the central region of the protein. The regions that have been shown to bind to target proteins, together with the identity of the interacting proteins, are shown.
