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Fig. 3. Regulation of cyclin D1. A working model depicts the cooperative effects of growth factor receptors and integrins on PI3K, ERK and Rac that regulate cyclin D1 levels. Each of these signaling components has the potential to stimulate the expression of cyclin D1 mRNA. Rac and PI3K are also involved in the translation and stabilization of cyclin D1 protein, respectively.





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