Fig. 1. K1735 primary tumor formation requires ß3 expression.
2x105 ß3-positive M2 cells or 2x105
ß3-antisense-expressing M2-Tß3 cells were injected transorally into
the floor of the mouth of syngeneic mice. After 4 weeks the mice were
sacrificed and evaluated for tumor formation. Note that the mice injected with
the M2 cells developed large primary tumors (A, left), whereas those injected
with the M2-Tß3 cells were considerably smaller (A, right). (B) The
average weight of tumors formed by M2 cells was 5.0 g (±1 g), whereas
tumors formed by the M2-Tß3 cells averaged 1.2 g (±0.4 g). 12 mice
were injected with each cell line.
