Fig. 8. A schematic diagram showing the basic cellular organisation of a prostatic
epithelial duct with a prevailing lumen potential of -10 mV, relative to the
stroma at earth potential (0 mV) (Szatkowski et al.,
2000). Assuming the thickness
of the epithelial cell layer to be 20 µm, the transcellular voltage
gradient would be equivalent to 5 V cm-1, as indicated. Thus, under
these electrophysiological conditions, epithelial cells expressing functional
VGSCs would be expected to migrate towards the lumen.
