Fig. 3. Sequence alignment of the six members of the tubulin superfamily in T.
brucei. Dark blue boxes indicate sequence identity, and light blue boxes
indicate sequence similarity, a minimum of three residues being shown in each
box. This manual alignment indicates the presence of a number of insertions
and deletions in the 
-, 
- and 
-tubulin sequence in
comparison with 
ß-tubulin. Secondary structural elements of pig
-tubulin are indicated (PDB number 1TUB) to suggest where these
insertions and deletions may be located. T1-T7 indicate loops that contain
amino acid residues directly involved in nucleotide contacts (Nogales et al.,
1998b).
