Fig. 4. Schematic representation of the alignment shown in
Fig. 3, indicating the location
of insertions and deletions in the T. brucei 
-, 
- and
-tubulin sequence. Red boxes indicate insertions and green chevrons
indicate deletions of >5 amino acids; the actual length of each
insertion/deletion is indicated. The proposed positions of these
insertions/deletions with reference to the secondary structural elements of
pig 
-tubulin shown in Fig.
3 are denoted; for instance, S9-H10 indicates an insertion present
on the loop between strand 9 and helix 10. The exact length of each tubulin
sequence is shown at the right-hand side of the figure. Also indicated are the
limits of the tubulin regions identified as the nucleotide-binding domain, the
intermediate domain and the C-terminal domain.
