Fig. 1. Conservation of phosphorylation site sequences within the MAP4 MT-binding
domain. Comparison of amino acid sequences from human (Chapin et al.,
1995), mouse (West et al.,
1991), bovine (Aizawa et al.,
1990), and Xenopus
(Shiina et al., 1999) shows
conservation of serines among species (696 and 787 positions in human MAP4
sequence), residing within proline-directed consensus sites for cyclin B-cdc2
kinase phosphorylation, highlighted in boxes. Identical amino acids among
species are represented by bars and deletions by asterisks. Note that the
region surrounding ser-696 is more highly conserved than that around
ser-787.
