Fig. 7. Conservation of the nuclear matrix-targeting signal in vertebrate species. Amino acid sequence alignments of the indicated Runx2 (Cbfa1/AML3), Runx1 (Cbfa2/AML1), and Runx 3 (Cbfa3/AML2/PEBP2
A) proteins from different vertebrate species including two species of fish (Danio rerio (Danio), zebrafish; Oryzias latipes (Oryzi), Japanese killifish or medaka). Alignments were performed using CLUSTALW and graphically depicted using the GeneDoc software developed by K. B. Nicholas and H. B. Nicholas. Amino acids were colored on the basis of similarities in physiochemical properties (H,K,R, dark blue; N,Q, light blue; S,T, orange; L,I,V, dark gray, A,G, light gray; F,Y,W, maroon; M,C, yellow; P, white). None of the amino acid sequences contains negatively charged amino acids (D,E).
