Fig. 1. Analysis of the sequence of Sec31p from P. falciparum. (A) Alignment of the amino acid sequences of the WD-40 domains of P. falciparum Sec31p and human Sec31A. Identical amino acids are repeated in the central line. Similar amino acids are denoted with a +. The residues that form the four WD-40 motifs of P. falciparum Sec31p and five of the six human WD-40 motifs are underlined. (B) Domain structure of PfSec31p. Approximate boundaries between the WD40 domain, the intervening domain, the proline-rich domain and the C-terminal domain are indicated. Regions produced as recombinant proteins for the generation of antibodies are indicated by solid lines.
