Fig. 2. Pathways in yeast tested for GGA involvement. Each of the molecules shown was tested for trafficking defects in strains lacking both GGA genes. Proteins with defective sorting and/or transport are highlighted in blue. Proteins with altered processing but normal transport are shown in green. Transport pathways unaffected by loss of GGA proteins are in black. The early and late endosomes are shown together as the prevacuolar compartment (PVC). Abbreviations: TGN, trans-Golgi network; ALP, alkaline phosphatase; CPS, carboxypeptidase S; CPY, carboxypeptidase Y.
