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Fig. 3. Molecular diversity of focal contacts and fibrillar adhesions in human fibroblasts. The cells were fixed 24 hours after plating and double labeled for {alpha}5-integrin and {alpha}v-integrin or for tensin and phosphotyrosine (PY). The right-hand images show, in a spectrum scale, the ratio between the two labeled components, calculated as previously described (Zamir et al., 1999). Note the contrast between the high {alpha}5/{alpha}v and tensin/PY ratios in the fibrillar adhesions (indicated by their red color in the ratio image) and the lower ratio values in the focal contacts (indicated by their yellow color). Arrows and arrowheads indicate examples of focal contacts and fibrillar adhesions, respectively.





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