Fig. 7. A model illustrating the contribution of MT dynamics to the regulation of centrosome cohesion. We propose that parental centrioles are held together by a flexible proteinaceous linker whose assembly and disassembly is controlled by phosphorylation. If some of the regulatory kinases and/or phosphatases display affinity for MTs, their relative concentrations at the centrosome will depend on the MT dynamics typical of an intact MT network (particularly a constant flux of tubulin subunits towards the centrosome-associated MT minus ends). Whereas phosphatase activity will tend to stabilize the linker, any excess of kinase activity will cause its disruption.
