Fig. 6. Deletion of pin1+ causes increased sensitivity to cyclosporin A (CsA) and okadaic acid (OA). (A) Sp1 (wild-type), Sp3 (wild-type), Sp23 (pin1
) and Sp25 (pin1) cells were streaked out on YES plates containing no CsA (top right), 10 µg/ml CsA (bottom left panel) or 60 µg/ml CsA (bottom right panel) followed by incubation at 32°C for 3 days. The top left panel shows the schematic diagram of how these strains were streaked out on a YES plate. (B) Sp1 (wild-type), Sp3 (wild-type), Sp23 (pin1) and Sp25 (pin1) cells were streaked out on YES plates containing no OA (left panel) or 5 µM OA (right panel) followed by incubation at 32°C for 3 days. The strains were arranged on the plates as in A.
