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Fig. 1. Architecture of the Dis1/TOG family of MAPs. TOG domains (light-blue boxes), HEAT-repeating units (small yellow boxes) (Neuwald and Hirano, 2000), and coiled-coil regions (small grey boxes) are shown in different members of the Dis1/TOG family from various organisms. The last TOG domain in the first and second groups is very degenerate at the primary sequences (Cassimeris et al., 2001).
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