Fig. 1. Activation of CFTR-mediated iodide efflux by cAMP agonists in IB3-1 cells. Iodide efflux experiments were carried out following a 2 hour incubation at 37°C with 250 µM MPB compound (closed symbols) or not (open symbols). (A,B) A cAMP elevating cocktail (Cock: 10 µM forskolin, 500 µM cpt-cAMP, 500 µM IBMX) stimulated iodide efflux after MPB-07 (A) or MPB-91 (B) treatment (n=8 for each). (C) Bar graphs of the cAMP-dependent iodide efflux in IB3-1 cells after MPB treatment (filled bars).*P<0.05; ***P<0.001.
