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Fig. 1. Amino acid comparison of actinin-4 and other EF-hand proteins. The region in actinin-4 that interacts with BP180 is conserved among actinin family members and contains two EF-hand domains. The schematic includes a comparison of the BP180-binding sequence in actinin-4 and the comparable EF-hand domains in actinin-1, calmodulin and myosin regulatory light chain (MRLC).





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