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Fig. 1. The organisation of SNARE helices and mutated residues in SNAP-25B. (A) Domain structure of SNAP-25B. (B) Alignment of the SNAP-25B helices that participate in the core complex. Residues are indicated that are mutated in the BoNT/E-resistant construct, Em, and in the Q/E mutants. (C) The structure of the core SNARE complex showing the helices from VAMP (red), syntaxin 1 (blue) and SNAP-25 (green).





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