Fig. 1. Mutagenesis of human emerin, targeting residues conserved with human LAP2ß. Shown are the aligned amino acid sequences of human emerin and human LAP2ß, starting with the LEM-domain of each protein (residue 1 of emerin; residue 110 of LAP2ß). Numbers on the top line refer to the LAP2ß sequence. The regions mutated in this study are indicated by lines; residues changed to alanine are indicated by A. The number below each line refers to the amino acid sequence of emerin, and names each cluster of mutations according to its most N-terminal altered residue. TMD, transmembrane domain.
