Fig. 1. Chimeric NT receptors and modeling of internalization-recycling processes. (A) Modeling of internalization-recycling processes showing the effects of drugs used in this study. (B) Putative seven-transmembrane topology of chimeric receptors indicating i3 portions of rat NTR1 (black line) and of mouse NTR2 (grey line). (C) Sequence alignment of the third intracellular loop (i3) of the rat NTR1 (rNTR1), the mouse and human NTR2 (mNTR2 and hNTR2, respectively). Invariant residues for all three NT receptors are highlighted in black. Identical amino acids of the two NTR2 are boxed. The location of residue 237 is emphasized by an asterisk. TM, transmembrane domain.
