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Fig. 6. Pharmacological evaluation of signaling pathways that mediate the
IGF-I-dependent cell survival of Null+ cells. Null+ cells were placed in
suspension and IGF-I (100 ng/ml), LY294002 (50 µM), or PD 98509 (50 µM)
were added as indicated. The cells were then incubated at 37°C for 20
hours, lysed, and caspase 3 activity present in the lysates was measured.
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