Fig. 1. let-502(sb106) and mel-11(it26) embryos display defects
during pseudocleavage and early cleavages. (A-F) A wild-type embryo during
pseudocleavage, pronuclear fusion, late first cell division, two-cell stage,
late second division and four-cell stage, respectively. (G-L) A
mel-11(it26) embryo during similar stages. White arrows indicate
ectopic furrows. (M-R) let-502(sb106) embryo at stages similar to the
wild-type embryo in (A-F). Pseudocleavage furrows either do not form or are
small in comparison with wildtype (compare A with M). Embryos that have
unsuccessful cleavages still form short furrows as indicated by the black
arrowhead (O), but these regress. This particular embryo underwent successful
cleavages during the next round of cell division, forming an abnormal
four-cell embryo (R). Wild-type (S), mel-11(it26) (U) and
let-502(sb106) (V) embryo dividing from the two- to the four-cell
stage. All are at the same cell cycle stage as judged by nuclear and spindle
morphology and the time since the previous division. Arrows indicate the AB
cell furrow, which completes cleavage early in mel-11(it26) and late
in let-502(sb106) relative to wildtype. Bars, 7 µm.
