Fig. 8. Schematic view of steps in calmodulin redistribution under microtubule
stabilising treatment with paclitaxel. The CaM initially remains associated
with centrosomal matrix and kinetochore-to-pole microtubules, as in control
cells. At the spindle pole the CaM-EGFP appears to subdivide from its
ring-like shape, along with entire fragments of the spindle, including
microtubules and associated kinetochores and chromosomes. Further repetition
of this process generates a multipolar spindle, with CaM seen in a ring-like
structure at each of these poles, some of which contain centrioles, and the
chromosomal material becomes disorganised.
