Fig. 1. (A) Constructs for multimeric FN7-10 (see Materials and Methods for
details). (B) A scale model of the FN7-10 trimer, constructed from the
coordinates of FN7-10 (Leahy et al.,
1996) (these were also used to model the six FN-III domains in
TNfn3-8) with the program RasMol (Sayle
and Milner-White, 1995). The FN3 domains are shown as a
spacefilling atomic model, and the 
-helices of CMP are indicated
schematically in a ribbon format. For comparison an integrin molecule is drawn
to scale (Carrell et al., 1985;
Nermut et al., 1988).
