Fig. 4. Histology of SPARC-null lens at 3 months of age. Sections of wt and
SPARC-null lenses were stained with hematoxylin and eosin. Loss of normal
shape of secondary fiber cells in SPARC-null lenses is shown. Comparable
center cortical anterior regions from +/+ (A,C,E,G) and SPARC-null
(-/-) lenses (B,D,F,H) are shown. Note that in the SPARC-null lens,
most of the secondary fiber cells have become rounded and swollen, and the
nucleus has been displaced toward the posterior capsule (B). Bar (A,B), 540
µm; bar (C-H), 18 µm.
