QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Chromosome condensation: maternal and paternal differences

Condensation of chromosomes is essential for mitosis and depends on their recruitment of condensin complexes containing structural maintenance of chromosomes (SMC) proteins and regulators such as CAP-D2. Is the condensation mechanism always the same? In zygotes, condensed paternal chromosomes are less compact than their maternal counterparts, but whether this reflects different condensation mechanisms has never been clear. Philippe Collas and co-workers now show that the condensation mechanisms of maternal and paternal chromosomes in mitotic zygotes do indeed differ (see p. 2931). They find that AKAP95 — a scaffold protein previously shown to recruit condensin to chromatin — is targeted to maternal chromosomes in the female pronucleus but does not enter the male pronucleus. In addition, using peptides that compete with AKAP95, the authors show that AKAP95 is required for recruitment of CAP-D2 to and condensation of maternal but not paternal chromosomes. Collas and co-workers conclude that an AKAP95-independent mechanism recruits condensin during paternal chromosome condensation in zygotes, suggesting that this could affect the degree of compaction of the condensed chromosomes.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Differential regulation of maternal and paternal chromosome condensation in mitotic zygotes

Jacqueline Bomar, Pedro Moreira, John J. Balise, and Philippe Collas
JCS 2002 115: 2931-2940. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?