Fig. 3. A model for chaperone and co-chaperone interactions with nuclear hormone receptors. Chaperones and co-chaperones play a role in the maturation and inactivation of nuclear hormone receptors. During maturation, Hsp70 (70) and Hsp(40) bind to the hormone-binding domain (HBD) of the receptor (in white), which is followed by the association of Hop and Hsp90 (90). Maturation of the aporeceptor complex is completed by dissociation of Hsp40, Hsp70 and Hop followed by association of p23 (23) and one of the immunophilins (I). Hormone binding and dissociation of Hsp90, p23 and the immunophilin changes the conformation of the receptor, which then translocates to the nucleus and activates transcription. Bag1 can associate with the activated receptor and inhibit the activities of the receptor for which it requires its Hsp70-binding domain. AD, activation domain; DB, DNA-binding domain (see text for References).

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