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mRNA surveillance: nonsense-mediated and non-stop

Inaccurate transcription, RNA-processing errors and lymphocyte gene rearrangements can all generate aberrant mRNAs whose translation would produce dominant negative proteins that disrupt cell function. Cells must detect and destroy such RNAs, but how do they discriminate them from normal mRNAs? In a Commentary on p. 3033, Eileen Wagner and Jens Lykke-Andersen discuss recent work that has identified two mRNA surveillance mechanisms that do this: nonsense-mediated decay (NMD) and non-stop decay. NMD destroys transcripts that contain premature termination codons (PTCs). The last exon-exon junction is marked with an exon junction complex (EJC), and, if a PTC is present upstream, a group of `Upf' proteins triggers degradation of the mRNA during translation. Non-stop decay, by contrast, targets RNAs that lack in-frame termination codons and does not involve Upf proteins. Instead it requires the GTPase Ski7. Ski7 binds to the empty A site in a ribosome that has reached the 3' end of an mRNA and then recruits a multisubunit complex of exonucleases, termed the exosome, to degrade the transcript.

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mRNA surveillance: the perfect persist

Eileen Wagner and Jens Lykke-Andersen
JCS 2002 115: 3033-3038. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?