Fig. 2. (A) Schematic of human occludin mRNA coding sequence showing complete (TM4⁺) and TM4^- isoforms based on RT-PCR sequence data. Black segments represent transmembrane domains and the shaded segment the proximal C-terminal domain deleted with TM4 in the TM4^- isoform. (B) Nucleotide and deduced amino acid sequence of the region deleted in human and African Green Monkey (AGM) TM4^- occludin isoform. AGM sequence identities with the human are represented by dots, while different residues are shown. Numbering of human nucleotide sequence refers to the published cDNA sequence (accession no. NM_002538.2). The entire TM4 domain is contained within the deleted region and is highlighted in bold.

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