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Stress granules: way stations for mRNA

Cells exposed to stress such as UV light or hyperosmolarity shut down translation of `housekeeping' mRNAs while upregulating that of stress-induced transcripts such as heat shock protein mRNAs. This response is accompanied by formation of cytoplasmic microdomains termed stress granules (SGs), with which housekeeping mRNAs (but not stress-induced mRNAs) become associated. In a Commentary on p. 3227, Paul Anderson and Nancy Kedersha discuss studies shedding light on the roles of SGs in the stress response. Recent work indicates that SGs share many components with polysomes but lack the large ribosomal subunit and contain two specific RNA-binding proteins, TIA-1 and TIAR, not present in ribosomes. In stressed cells, TIA-1 and TIAR promote assembly of translational preinitiation complexes lacking the initiation factors eIF2 and eIF5 after stress signalling has reduced the availability of eIF2-GTP-tRNA<sub>i</sub><sup>Met</sup>. SGs could thus function as storage depots for untranslated mRNAs; however, given the dynamic movement of mRNAs into and out of SGs, Anderson and Kedersha propose that they are more likely to be `way stations' via which mRNAs must pass before being translated or degraded.

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Stressful initiations

Paul Anderson and Nancy Kedersha
JCS 2002 115: 3227-3234. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?