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Fig. 5. A blockade of gap junctions decreases the viability of neural progenitors.
Single cell suspensions of striatal progenitors were grown for 3 days in the
presence of either the uncoupling agent 18-ß-glycyrrhetinic acid
(ßGA) or its inactive analog glycyrrhyzic acid (GZA). The size of
neurospheres was reduced by ßGA (C,D) in comparison with that of
GZA-treated ones (A,B). This effect was reversible (rev), as the size of
floating neurospheres pre-treated with ßGA (G-H) was similar to that of
GZA-treated cultures (E-F) following an additional 4 day recovery period, as
described in the Materials and Methods. Bar, 300 µM (A-D); 780 µM
(E-H).
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