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Regulated targeting of TIF1ß to heterochromatin

TIF1ß is a developmentally regulated transcriptional corepressor proposed to function by reorganizing higher-order chromatin structure. It is essential for early embryogenesis and interacts with heterochromatin-associated protein 1 (HP1), a heterochromatin component implicated in Drosophila position effect variegation — the heritable pattern of silencing produced by positioning of genes close to pericentric heterochromatin. Speculating that nuclear compartmentalization of TIF1ß might be important for its function, Pierre Chambon and co-workers have examined its subnuclear distribution during differentiation of F9 embryonal carcinoma cells (see p. 3439). They find that TIF1ß has a dispersed (euchromatic) distribution in the nucleoplasm of undifferentiated cells but relocates to centromeric heterochromatin following differentiation induced by retinoic acid. No such relocation occurs in growth-arrested cells or RA-resistant cells. The authors show that mutation of the TIF1ß PxVxL motif that mediates interactions with HP1 blocks targeting of TIF1ß to centromeric heterochromatin. They therefore conclude that nuclear compartmentalization of TIF1ß is dynamically regulated by HP1 interaction during differentiation, speculating that TIF1ß might mediate cell-type-specific gene silencing by recruiting target genes to the transcriptionally inactive heterochromatic compartment.

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Cell differentiation induces TIF1ß association with centromeric heterochromatin via an HP1 interaction

Florence Cammas, Mustapha Oulad-Abdelghani, Jean-Luc Vonesch, Yolande Huss-Garcia, Pierre Chambon, and Régine Losson
JCS 2002 115: 3439-3448. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?