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The Smad network

Signalling by members of the transforming growth factor ß (TGF-ß) superfamily depends on a group of intracellular signalling molecules termed Smads. R-Smads are phosphorylated by the Ser/Thr kinase receptors to which these ligands bind; the R-Smads can then heterodimerize with a Co-Smad, enter the nucleus and regulate gene expression. In Cell Science at a Glance (see p. 3355 + poster), Aristidis Moustakas surveys the Smad signalling network, detailing its cytoplasmic and nuclear aspects, as well as the regulatory mechanisms that operate.

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Smad signalling network

Aristidis Moustakas
JCS 2002 115: 3355-3356. [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?