Fig. 3. Expression of specific mRNA levels in testes of normal mice and AR-null mice. The level of each mRNA species is expressed relative to an external standard (luciferase). Within each age group, different letter superscripts indicate a significant difference in mRNA levels (P<0.05). Results show means±s.e.m. of between four and six animals in each group. (A) Genes expressed at normal or increased levels in AR-null mice. 3ßHSD I, 3ß-hydroxysteroid dehydrogenase type I; P450scc, cytochrome P450 side chain cleavage; LH-R, luteinising hormone receptor; StAR, steroidogenic acute regulatory protein, Ren 1, renin type 1; TSP-2, thrombospondin type 2. (B) Genes with barely detectable levels of expression in AR-null mice. 17ßHSD III, 17ß-hydroxysteroid dehydrogenase type III; PGD, prostaglandin D-synthetase; 3ßHSD VI, 3ß-hydroxysteroid dehydrogenase type VI. (C) Genes with reduced levels of expression in AR-null mice. RLF, relaxin-like factor; GST5-5, glutathione S-transferase 5-5; P450c17; cytochrome P450 17-hydroxylase; EH, epoxide hydrolase; EST, estrogen sulfotransferase.

Return to article