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tau mRNA trafficking

Transport of mRNAs to specific subcellular regions — and their subsequent local translation — is important for the development of polarity and normal function in many cell types, particularly neurons. Protein complexes containing cytoskeletal motors that mediate transport appear to bind to specific sequences in these mRNAs, but in most cases the identities of the proteins involved are not known. Irith Ginzburg and co-workers have therefore investigated trafficking of mRNA encoding the neuronal cytoskeletal protein tau, which is targeted to axons by an axonal-localization sequence (ALS) in its 3' untranslated region (see p. 3817). Using biochemical and morphological methods, they demonstrate that the RNP granules in which tau mRNA is transported also contain the kinesin-family microtubule motor KIF3A and HuD — an RNA-binding and stabilizing protein that binds to the ALS and the authors show immunoprecipitates with KIF3A. Ginzburg and co-workers also demonstrate that antisense KIF3A mRNA blocks axonal targeting of tau mRNA. They therefore propose that KIF3A drives trafficking of this RNA along microtubules and that HuD functions as an adaptor that links it to the motor.

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Related articles in JCS:

Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules

Stella Aronov, Gonzalo Aranda, Leah Behar, and Irith Ginzburg
JCS 2002 115: 3817-3827. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?