Fig. 2. Structure of 53BP2 showing the site of interaction with PP1c. 53BP2 is represented as a ribbon structure on the basis of the crystal structure of 53BP2 (residues 796-1005) in complex with p53 (Gorina and Pavletich, 1996), which is available in the protein database at the NCBI. Residues 796GMRVKFN802 encompassing the RVxF motif at 798-801 (Helps et al., 1995) are mobile in the crystal and therefore not visible in the crystal structure. In the figure, Phe801 (depicted in red) and Asn802 have been added to the structure and illustrate that the position of the RVxF motif is highly exposed at the end of the ankyrin repeats (backbone indicated in green). The backbone of the SH3 domain of 53BP2 is indicated in purple.
